The island of Mykonos is well connected with direct flights from major Italian and foreign airports, direct flights from Milan, Bologna, Verona, Venice, Pisa, Naples, Bergamo, Florence, Turin and Rome in about 2 hours and 40 minutes
You can also get to Mykonos by ferry from Ancona and Bari to Patras. From Patras to Athens there are 220 km. On board you can book the bus to the port of Piraeus.